Antibacterial Activity of Melia azedarach Leaves against Salmonella typhi and Streptococcus pneumoniae

An antiviral meliacarpin from leaves of Melia azedarach L.

Bioassay guided purification of the ethyl acetate extract of leaves of Melia azedarach led to the isolation of the limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin, which showed IC50 values of 6 microM and 20 microM for vesicular stomatitis (VSV) and herpes simplex (HSV-1) viruses, respectively. Its structure was established by spectroscopic methods.

Anti-moulting activity in Brazilian Melia azedarach.

In vitro anti-Junin virus activity of a peptide isolated from Melia azedarach L. leaves.

Meliacine, a peptide isolated from leaves of Melia azedarach L. inhibited the multiplication of Junin virus in Vero cells treated with the compound before infection (pre-treatment) or immediately after virus adsorption. Analysis of early events following infection demonstrated that meliacine blocks virus penetration by preventing the uncoating step. The addition of meliacine at different times ...

Evaluation of the antibacterial activity of selected Pakistani honeys against multi-drug resistant Salmonella typhi

BACKGROUND The development of resistance to conventional anti-typhoid drugs and the recent emergence of fluoroquinolone resistance have made it very difficult and expensive to treat typhoid fever. As the therapeutic strategies become even more limited, it is imperative to investigate non-conventional modalities. In this context, honey is a potential candidate for combating antimicrobial resista...

Antibacterial, Preliminary Phytochemical and Pharmacognostical Screening on the Leaves of Vicoa indica (L.)DC.

The aim of the present research was focused on the antibacterial, preliminary phytochemical and pharmacognostical properties of Vicoa indica (L.)DC. via in vitro approach. The aqueous and organic solvent (hexane, chloroform and methanol) extracts from the leaves of Vicoa indica (Asteraceae) were tested against Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Vibrio parahaemolyt...